Globus pallidus dynamics reveal covert strategies for behavioral inhibition
نویسندگان
چکیده
منابع مشابه
Microstimulation-induced inhibition of neuronal firing in human globus pallidus.
Neurosurgical treatment of Parkinson's disease (PD) frequently employs chronic high-frequency deep brain stimulation (DBS) within the internal segment of globus pallidus (GPi) and can very effectively reduce L-dopa-induced dyskinesias and bradykinesia, but the mechanisms are unknown. The present study examined the effects of microstimulation in GPi on the activity of neurons close to the stimul...
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A 41-year-old man was found unconscious at his home by a friend. He was immediately admitted to the hospital through the emergency department. At the emergency department he regained consciousness. He mentionned he had a few alcoholic beverages the night before but otherwise clinical history was negative. On physical examination swelling of the right orbital area was evident. Further clinical h...
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Extracellular recordings in primates have identified two types of neurons in the external segment of the globus pallidus (GPE): high frequency pausers (HFP) and low frequency bursters (LFB). The aim of the current study was to test whether the properties of HFP and LFB neurons recorded extracellularly in the primate GPe are linked to cellular mechanisms underlying the generation of action poten...
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The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine the electrophysiological effects of neurokinin-1 receptor activation in globus pallidus, whole-cell patch-clamp recordings were performed in t...
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ژورنال
عنوان ژورنال: eLife
سال: 2020
ISSN: 2050-084X
DOI: 10.7554/elife.57215